A comparative evaluation of butorphanol, fentanyl and nalbuphine for total intravenous anaesthesia in laparoscopic cholecystectomy

Introduction: The study compared the effectiveness of opioids: butorphanol, fentanyl and nalbuphine as a part Total Intra Venous Anaesthesia (TIVA) using propofol an inducing agent in all three groups laparoscopic cholecystectomy view haemodynamic stability, analgesia recovery characteristics. Aims: To compare efficacy opioids viz. TIVA Haemodynamics variables, Material Methods: This randomised prospective was conducted ninety patients ASA grade I either sex, age group 20- 60 yrs weighing 30- 70 kg undergoing cholecystectomy. Patients received 25 μg/kg inj. butorphanol intravenously, II 2 intravenously III 0.3 mg/kg just before induction anaesthesia. Induction carried out exclusively with IV agents vecuronium bromide 100μg/kg intravenously. maintained infusion according to Bristol regimen intermittent top-up doses muscle relaxant. Haemodynamic monitoring, characteristics form emergence time time, duration analgesia, sedation any side effects were recorded. Results: In our study, it found that better steady state haemodynamics throughout intraoperative period nalbuphine. attenuation pressor response again although also suppressed this some extent. parameters, showed slow comparison whereas provided than other two drugs. Conclusion: conclude, demonstrated agonist-antagonist type can be suitable alternative scheduled agonist like fentanyl.